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-synuclein, which happens to be a primary part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, which can be an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) worry, counsel that dysfunction with the intracellular proteinase methods, which include ubiquitin-proteasome method or lysosomal procedure, which eliminates avo